Journal of Bioinformatics and Proteomics Review Introduction

At present, whole genome sequences are reasonably available for many organisms. However, genomics alone is insufficient in providing comprehensive information on the mechanisms underlying the biological processes of an organism. With the development of various proteomic technologies, proteomics has enhanced our understanding of biological processes on a global scale. Enormous efforts have been exerted to deeply inspect microbial systems using proteomic technologies. Inspiring progress and achievements have facilitated our understanding of the cellular physiology of microorganisms in many aspects. In this review, we present different proteomic technologies and advances, and enumerate their significant applications in microbial studies. Proteomic studies provide identification or/and quantitative measurement for proteins from microorganisms. This review discussed the molecular physiology of microbial systems when facing external environmental stimuli, and illustrated the pathogenic mechanisms of microbial pathogens and their significance to clinical vaccine selection on a proteomic scale. Last but not least, the review quoted some important studies of microbial metaproteomics. *Corresponding author: Fuchu He, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China, Tel: +86021-54237155; E-mail: [email protected] Received date: June 08, 2015 Accepted date: February 03, 2016 Published date: February 04, 2016